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Characterizing Heterogeneity

In the past two decades, some diseases have achieved major research progress. In recent years, single cell research techniques have continued to advance, setting off a wave of research on tumor heterogeneity. Single Cell has established advanced single cell omics platforms to assist you with single cell services and provide you with accurate and comprehensive analysis results through bioinformatics.

Uncover the Tumor Heterogeneity

Cancer is a dynamic disease. In general, as a disease progresses, cancers become more diverse. As a result of this heterogeneity, the bulk tumor may contain a variety of cells with distinct molecular signatures and varying degrees of treatment sensitivity. This heterogeneity may lead to the non-uniform distribution of genetically distinct tumor-cell subpopulations across and within disease sites (spatial heterogeneity) or temporal variations in the molecular composition of cancer cells (temporal heterogeneity). Therefore, an accurate assessment of tumor heterogeneity is essential for the development of effective therapies. Multiregion sequencing, single-cell sequencing, analysis of autopsy samples, and longitudinal analysis of liquid biopsy samples are all promising emerging technologies for dissecting the complex clonal architecture of cancers.

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Intra-tumor heterogeneity in different cancer types.
Models for circulating tumor cell development and cancer progression.

Uncover the Somatic Cell Heterogeneity

Somatic stem cells are adult-derived cells with two defining characteristics: the capacity to undergo differentiation and generate multiple lineages over extended periods, and the capacity to self-renew simultaneously. Traditionally, the stem cell pool within a single tissue was believed to be homogeneous, with all stem cells having the same differentiation and self-renewal potential. In many somatic tissues, the stem cell system is surprisingly heterogeneous, containing different types of stem cells, such as those from hematopoietic, skin, and intestinal epithelium, according to recent data generated by new technologies.

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Uncover the Heterogeneity of Immunity Associated Microbiome

Host immunity plays a critical role in regulating clinical responses to various treatments. Recently, the gut microbiome has been demonstrated to play a major role in mediating overall immune set-point, via various effects on local and systemic inflammatory processes. Scientists have found that quantifiable differences in the microbiome are associated with disease and treatment outcomes. However, the detailed mechanisms of immune-microbiome interactions have not been clarified. Single cell technologies provide a powerful tool to investigate and explore the heterogeneity of immunity-associated microbiomes.

Tumor infiltrated immune cells.
! ! For Research Use Only. Not for diagnostic or therapeutic purposes.