Single Cell Omics Solutions for Neutrophils
Creative Biolabs provides a comprehensive suite of single-cell analysis services, including single-cell sequencing, functional analysis, and analytical development. Our goal is to advance your immunotherapy at the single cell level for a wide range of cancer treatments. We have built a team of talented and motivated scientists and technicians to pursue our commitment.
Single Cell Omics Solutions for Neutrophils
Single-cell omics analysis has been considered as a powerful tool for investigating the cell process in disease development and regulation. However, recent studies suggest that the heterogeneity of different cell populations causing by abnormal cell behaviors and micro-environment is strongly related to various tumor cell-state transitions of immunotherapy. Single-cell technologies provide a unique opportunity of characterizing cell functional states and their transitions by quantifying a wide collection of biological parameters at the single-cell level. Currently, a number of tumor infiltrated immune cells, such as T cells, B cells, dendritic cells (DCs), macrophages, as well as neutrophils, have been detected by single-cell transcriptomic or proteomic assays. For example, single-cell RNA sequencing (scRNA-seq) technologies have been developed to assess the neutrophil-dependent immune responses against sarcoma in human samples. The results have illustrated that neutrophil infiltration and type 1 immunity play critical roles in treating human tumors in the clinic.
Fig.1 Multimodal and integrative methods for single-cell analyses. (Stuart, 2019)
Our Integrative Single Cell Omics Platform for Neutrophils
In the past few years, Single Cell has developed a comprehensive set of platforms for measuring different kinds of cell parameters in cancer immunotherapy. A wide variety of methods have been widely applied to determine the functional state, the lineage, as well as pseudo-temporal ordering in neutrophils, including fluorescence-activated cell sorting (FACS), single-cell RNA sequencing (scRNA-seq), and canonical correlation analysis (CCA). In a recent study, the protein abundance of neutrophils has been detected by scRNA-seq approaches, and Cas9 in pooled genetic screens, allowing system-wide single-cell transcriptional profiling. In addition, cell lineage can also be evaluated based on a Cas9 lineage sequencing array. Our platforms can provide a comprehensive single-cell omics analysis and bring your novel target candidate to cancer therapy applications.
Fig.2 scRNA-seq methods for the analysis of cell transcriptomes. (Stuart, 2019)
Creative Biolabs has developed fail-proof single-cell analysis platforms for our clients all over the world. We have integrated high-quality single-cell omics solutions that are based in America and span the entire development chain from discovery to commercialization. Our company offers the best guarantee in every step and has successfully developed a series of neutrophils-targeting single-cell assays. If you are interested in our services, please feel free to contact us for closer communication to learn how we can be involved in your project. Separate services or integrated end-to-end solutions are all welcomed.
Reference
- Stuart, T., et al. Integrative single-cell analysis. Nat Rev Genet. 2019, 20(5): 257-272.
